Cat. #154270
AEG-1?HEP mouse
Cat. #: 154270
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Hepatocellular Carcinogenesis; Chronic Inflammation
Model: Conditional KO
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Contributor
Inventor: Devanand Sarkar
Institute: Virginia Commonwealth University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: AEG-1?HEP mouse
- Tool sub type: Mouse
- Disease: Hepatocellular Carcinogenesis; Chronic Inflammation
- Model: Conditional KO
- Conditional: Yes
- Conditional description: Conditional AEG-1ÎHEP knockout after single i.p. injection of 10Âľg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water.
- Description: Mouse model with conditional AEG-1 knockout in hepatocytes
- Genetic background: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with Alb/Cre (B6.Cg-Tg(Alb-cre)21Mgn/J)
- Phenotype: Hepatocellular Carcinogenesis
- Zygosity: unknown
- Strain: C57BL/6
- Production details: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with Alb/Cre (B6.Cg-Tg(Alb-cre)21Mgn/J)
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Astrocyte Elevated Gene-1
References
- Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.
- Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
