#154170

PARG Inhibitor PDD00017238 Small Molecule (Tool Compound)

Cat. #154170

PARG Inhibitor PDD00017238 Small Molecule (Tool Compound)

Cat. #: 154170

Sub-type: Inhibitor

Availability: Please enquire for quantities and pricing

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Allan Jordan

Institute: Cancer Research UK, Manchester Institute

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: PARG Inhibitor PDD00017238 Small Molecule (Tool Compound)
  • Alternate name: EP3233845
  • Tool sub type: Inhibitor
  • Primary target: Poly(ADP-ribose) Glycohydrolase (PARG)
  • Description: Exploiting the DNA damage response for cancer therapy relies on the fact that rapidly proliferating cancer cells have higher incidences of DNA damage, defective DNA repair pathways, genomic instability, or a combination of these facets. 1-3 Poly(ADP-ribosylation) is a post-translational modification that plays an important role in the repair of damaged sections of DNA.4-6 Poly(ADP-ribose) polymerases (PARPs), in particular PARP1, signal the presence of DNA damage and facilitate DNA repair. ...
  • Purpose: Inhibitor

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Primary target: Poly(ADP-ribose) Glycohydrolase (PARG)

References

  • J. Med. Chem.2018612310767-10792