Anti-Big (high-molecular-weight) tau

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-Big (high-molecular-weight) tau
• Tool sub type: Primary antibody
• Class: Polyclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Reactivity: Rat
• Host: Rabbit
• Application: IHC ; WB
• Description: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great s...
• Immunogen: Recombinant protein of the complete 4a exon of tau, specific to the Big tau isoform, was used to produce antibody

Target Details

• Target: Big tau (high-molecular-weight)
• Tissue cell line specificity: Rabbit
• Target background: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great s...

Applications

• Application: IHC ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Boyne et al. 1995. J Comp Neurol. 358(2):279-93. PMID: 7560287.
• Distribution of Big tau in the central nervous system of the adult and developing rat.