Cat. #153989
Anti-TTP
Cat. #: 153989
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Tristetraprolin
Class: Polyclonal
Application: IP ; WB
Reactivity: Human ; Mouse
Host: Rabbit
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Pavel Kovarik
Institute: University of Vienna
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-TTP
- Alternate name: TTP, ZFP36 Ring Finger Protein, Growth Factor-Inducible Nuclear Protein NUP475 G/G1 Switch Regulatory Protein 24, RNF162A, Zfp-36, NUP475, GS24, TIS11
- Tool sub type: Primary antibody
- Class: Polyclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 36 kDa
- Reactivity: Human ; Mouse
- Host: Rabbit
- Application: IP ; WB
- Description: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3ÄËĂÂĂÂ-untranslated regions (3ÄËĂÂĂÂUTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. ...
- Immunogen: 34 C-terminal amino acids of TTP fused to GST
Target Details
- Target: Tristetraprolin
- Molecular weight: 36 kDa
- Tissue cell line specificity: Rabbit
- Target background: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP ...
Applications
- Application: IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.
- Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammationresolution.
- Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.
- Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.
- Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.
- Tristetraprolin is required for full anti-inflammatory response of murine macroph...
