Cat. #153778
Anti-IREB2 [IREB2-46-18-1]
Cat. #: 153778
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: IREB2, Uniprot ID:Q811J3
Class: Monoclonal
Application: ELISA ; IP ; WB
Reactivity: Mouse
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Bruno Galy
Institute: Deutsches Krebsforschungszentrum (DKFZ)- German Cancer Research Center
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-IREB2 [IREB2-46-18-1]
- Alternate name: Iron regulatory protein 2 (IREB2)
- Clone: Xbio/DK/IREB2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Mouse
- Host: Rat
- Application: ELISA ; IP ; WB
- Description: Monoclonal antibody which binds IREB2, involved in iron homeostasis. Background and Research Application IREB2 (iron regulatory protein 2) is an RNA binding protein and a central regulator of cellular iron homeostasis. This protein regulates iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. In humans IREB2 polymorphism is linked to chronic obstructive pulmonary disease (CPOD), lung cancer and Alzheimer's disease. IREB2-null mice suffer from anaemia, abnormal body iron distribution, and neurodegeneration. IREB2 also plays various roles in cancer.
- Immunogen: Full length His-tagged IREB2 of mouse origin, produced in E. coli
- Immunogen uniprot id: Q811J3
- Isotype: IgG2a
- Production details: Supernatant containing the monoclonal antibody is obtained from culturing the hybridoma
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: IREB2, Uniprot ID:Q811J3
- Target background: Monoclonal antibody which binds IREB2, involved in iron homeostasis. Background and Research Application IREB2 (iron regulatory protein 2) is an RNA binding protein and a central regulator of cellular iron homeostasis. This protein regulates iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. In humans IREB2 polymorphism is linked to chronic obstructive pulmonary disease (CPOD), lung cancer and Alzheimer's disease. IREB2-null mice suffer from anaemia, abnormal body iron distribution, and neurodegeneration. IREB2 also plays various roles in cancer.
Applications
- Application: ELISA ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: Cell Culture Supernatant with 0.02% Sodium Azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
References
- Not published yet (as of 08/08/2018)
