Anti-Follistatin 288 [17-2]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-Follistatin 288 [17-2]
• Alternate name: Follistatin, FS, FST, Active-binding protein
• Clone: 15
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 37 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; IHC ; WB
• Description: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. Clone 17/2 recognizes recombinant human Follistatin 288, allowing for detection of FSH levels using various analysis methods. This antibody also works in a two site ELISA with Clone 29/9.
• Immunogen: Recognizes human Follistatin isoform FS288, raised against recombinant human FS288
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14
• Recommended controls: Testis

Target Details

• Target: Follistation 288
• Molecular weight: 37 kDa
• Tissue cell line specificity: Testis
• Target background: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. Clone 17/2 recognizes recombinant human Follistatin 288, allowing for detection of FSH levels using various analysis methods. This antibody also works in a two site ELISA with Clone 29/9.

Applications

• Application: ELISA ; IHC ; WB

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Shipping at 4° C

References

• Hands et al. 2013. Anal Bioanal Chem. 405(23):7347-55. PMID: 23831829.
• Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors.
• Fitzgerald et al. 2012. Invest Ophthalmol Vis Sci. 53(11):7358-69. PMID: 23010638.
• The effects of transforming growth factor-?2 on the expression of follistatin and activin A in normal and glaucomatous human trabecular meshwork cells and tissues.
• Mabuchi et al. 2006. Oncol Rep. 15(2):291-6. PMID: 16391844.
• Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma.
• Pratic et al. 2004. Chem Phys Lipids. 128(1-2):165-71. PMID: 15037161.
• F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.
• Evans et al. 1998. J Endocrinol. 156(2):275-82. PMID: 9518873.
• Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin.
• Majdic et al. 1997. Endocrinology. 138(5):2136-47. PMID: 9112414.
• Testicular expression of inhibin and activin subunits and follistatin in the rat and human fetus and neonate and during postnatal development in the rat.