#153177

Anti-Acetyl SMC3 [DP3.1]

Cat. #153177

Anti-Acetyl SMC3 [DP3.1]

Cat. #: 153177

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Acetyl SMC3

Class: Monoclonal

Application: WB

Reactivity: Xenopus laevis

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Julian Gannon

Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details
Target Details
Applications
Handling

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Acetyl SMC3 [DP3.1]
  • Clone: DP3.1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 141 kDa
  • Reactivity: Xenopus laevis
  • Host: Mouse
  • Application: WB
  • Description: SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.SMC3 is unacetylated in egg extracts. It is only acetylated in chromatin preparations from extracts where the DNA has replicated.
  • Immunogen: Synthetic peptide - EEVSLRRVIGAKacetyl Kacetyl DQYFLDKK
  • Recommended controls: Xenopus chromatin extract

Target Details

  • Target: Acetyl SMC3
  • Molecular weight: 141 kDa
  • Tissue cell line specificity: Xenopus chromatin extract
  • Target background: SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.SMC3 is unacetylated in egg extracts. It is only acetylated in chromatin preparations from extracts where the DNA has replicated.

Applications

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C