Cat. #152588
Anti-CD45RO [UCH-L1]
Cat. #: 152588
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RO)
Class: Recombinant
Application: FACS ; IHC ; IP ; WB
Reactivity: Human
Host: Mouse
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Peter Beverley
Institute: Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-CD45RO [UCH-L1]
- Clone: rUCH-L1
- Tool sub type: Primary antibody
- Class: Recombinant
- Conjugation: Unconjugated
- Molecular weight: 180 kDa
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC ; IP ; WB
- Description: PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of functional T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny.
- Immunogen: Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus.
- Isotype: IgG2a
Target Details
- Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RO)
- Molecular weight: 180 kDa
- Target background: PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of Fn T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny.
Applications
- Application: FACS ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS only
- Storage conditions: -20° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-CD45RO [UCH-L1]
References
- Original hybridoma first published in Smith et al. 1986. Immunology. 58(1):63-70. PMID: 2423439.
- Fn subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.
