Cat. #152488
Anti-CD29 [8E3]
Cat. #: 152488
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Integrin beta-1 (CD29), VLA-4 subunit beta
Class: Monoclonal
Application: ELISA ; IHC ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Martin Humphries
Institute: University of Manchester
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-CD29 [8E3]
- Alternate name: Integrin Subunit Beta 1; Glycoprotein Iia; MSK12; GPIIA; FNRB; MDF2; Very Late Activation Protein; Beta Polypeptide; Fibronectin Receptor Subunit Beta; Integrin VLA-4 Beta Subunit; CD29 Antigen; VLA-BETA; CD29; VLAB
- Clone: Array
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IP ; WB
- Description: Integrin beta1 (CD29) is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
- Immunogen: Purified Integrin Beta1 from HT-1080 cells.
- Isotype: IgG1 kappa
- Recommended controls: HT-1080 cell lysate
Target Details
- Target: Integrin beta-1 (CD29), VLA-4 subunit beta
- Tissue cell line specificity: HT-1080 cell lysate
- Target background: Integrin beta1 (CD29) is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the Fn receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
Applications
- Application: ELISA ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Tiwari et al. 2011. J Cell Sci. 124(Pt 10):1672-80. PMID: 21511727.
- Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking.
- Bridger et al. 2008. Biol Reprod. 79(2):274-82. PMID: 18417711.
- Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows.
- Mould et al. 2005. J Biol Chem. 280(6):4238-46. PMID: 15557320.
- Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.
