Cat. #152414
Anti-HPV18E6 [C1X1]
Cat. #: 152414
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Human papillomavirus type 18 (HPV18) E6 protein
Class: Monoclonal
Application: IP ; WB
Reactivity: Human papilloma virus
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Lawrence Banks
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-HPV18E6 [C1X1]
- Clone: C1X1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human papilloma virus
- Host: Mouse
- Application: IP ; WB
- Description: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
- Immunogen: HPV-18 E6-beta-galactosidase fusion protein
- Isotype: IgG3
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Human papillomavirus type 18 (HPV18) E6 protein
- Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Applications
- Application: IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
- Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.
