#151903

Anti-Keratin K1 [LHK1]

Cat. #151903

Anti-Keratin K1 [LHK1]

Cat. #: 151903

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Keratin 1

Class: Monoclonal

Application: IHC ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Nick Tidman

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Keratin K1 [LHK1]
  • Clone: LHK1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 68 kDa
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.
  • Immunogen: 13-amino acid (1 .75-kd) sequence (VRFVSTSYSGVTR) of the K1 polypeptide C terminus
  • Isotype: IgG2a kappa
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: Keratin 1
  • Molecular weight: 68 kDa
  • Target background: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.

Applications

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Bloor et al. 2003. Am J Pathol. 162(3):963-75. PMID: 12598329.
  • Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.
  • Waseem et al. 1999. J Invest Dermatol. 112(3):362-9. PMID: 10084315.
  • Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.
  • Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880.
  • Activated keratinocytes in the epidermis of hypertrophic scars.
  • Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
  • Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.