Cat. #151889
DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)
Cat. #: 151889
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of ÎłH2AX foci after ionizing radiationâinduced or etoposide-induced DNA damage. NU7441 (0.5 ÎźM or 1 ÎźM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...
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Contributor
Inventor: Bernard Golding ; Laurent Rigoreau
Institute: Newcastle University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)
- Alternate name: DNA-dependent protein kinase (DNA-PK) inhibitor NU7441
- Molecular formula: C25H19NO3S
- Tool sub type: Inhibitor
- Primary target: DNA-dependent protein kinase (DNA-PK)
- Description: NU7441 is a highly potent and selective DNA-PK inhibitor.
- Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of ÎłH2AX foci after ionizing radiationâinduced or etoposide-induced DNA damage. NU7441 (0.5 ÎźM or 1 ÎźM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...
- Purpose: Inhibitor
- Selectivity: Also inhibits PI3K with IC50 of 5 ÎźM in cell-free assays.
- Molecular weight: 413.49 g/mol
Handling
- Purity: 413.49 g/mol
- Shipping conditions: Dry Ice
Target Details
- Primary target: DNA-dependent protein kinase (DNA-PK)
- Ic50: 14 nM
Application Details
- Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of ÎłH2AX foci after ionizing radiationâinduced or etoposide-induced DNA damage. NU7441 (0.5 ÎźM or 1 ÎźM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...
References
- Zhao et al. 2006. Cancer Res. 66(10):5354-62. PMID: 16707462.
- Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
- Leahy et al. 2004. Bioorg Med Chem Lett. 14(24):6083-7. PMID: 15546735.
- Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
