Cat. #151887
Anti-ATRX [23c]
Cat. #: 151887
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: ATRX
Class: Monoclonal
Application: IHC ; IF ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Helen Turley
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-ATRX [23c]
- Alternate name: RAD54, XNP
- Clone: 23c
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IHC ; IF ; WB
- Description: Monoclonal antibody which detects a commonly mutated telomere regulator.
- Immunogen: Recombinant Protein
- Immunogen uniprot id: P46100
- Isotype: IgG3 kappa
- Myeloma used: P3/NS1/1-Ag4.1
- Recommended controls: HeLa and L929 cells
Target Details
- Target: ATRX
- Tissue cell line specificity: HeLa and L929 cells
- Target background: ATRX is a transcriptional regulator which is required for deposition of the histone variant H3.3 at telomeres and other genomic repeats. This is important to maintain silencing at these sites. ATRX mutations are associated with an X-linked mental retardation (XLMR) syndrome ATRX is commonly mutated in cancers which maintain their telomeres by a telomerase independent pathway. This generates alternative lengthening of telomeres.
Applications
- Application: IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-ATRX [39f]
References
- Cooper et al. 2016. Nat Commun. 7:13661. PMID: 27892467.
- Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
- McDowell et al. 1999. Proc Natl Acad Sci U S A. 96(24):13983-8. PMID: 10570185.
- Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.
