#151289

Anti-TCR CBeta1 [JOVI.1] mAb

Cat. #151289

Anti-TCR CBeta1 [JOVI.1] mAb

Cat. #: 151289

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: TCR CBeta1

Class: Monoclonal

Application: WB ; FACS ; IHC ; IF ; IP

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Mike Owen

Institute: Cancer Research UK, Lincoln's Inn Fields Institute

Primary Citation: Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-TCR CBeta1 [JOVI.1] mAb
  • Clone: JOVI.1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Cell signalling pathway: TCR signalling
  • Reactivity: Human
  • Host: Mouse
  • Application: WB ; FACS ; IHC ; IF ; IP
  • Description: Monoclonal antibody specific for the variable region of T cell receptors in humans. This antibody aids the study of T-cell mediated diseases.

    Anti-TCR CBeta1 [JOVI.1] mAb recognises an epitope on the majority of TCRs.

    Anti-TCR CBeta1 [JOVI.1] mAb is capable of inducing proliferation of peripheral blood T cells.
  • Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
  • Immunogen uniprot id: P01850
  • Isotype: IgG2a
  • Myeloma used: P3/NS1/1-Ag4.1

Target Details

  • Target: TCR CBeta1
  • Target background: The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor beta locus have been associated with T cell lymphomas. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI.1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V beta regions.

Applications

  • Application: WB ; FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-TCR C?1, Recombinant [JOVI.1]

References

  • Rossatti et al. 2019. Cells. 8(11):1-13. PMID: 31690048.
  • Beck et al. 2018. Hum Vaccin Immunother. 14(12):2864-2873. PMID: 30111232.
  • Tesio et al. 2018. Hemasphere. 2(2):e38. PMID: 31723766.
  • Risueño et al. 2008. PLoS ONE. 3(3):e1747. PMID: 18320063.
  • Chen et al. 2007. J Biol Chem. 282(48):35361-72. PMID: 17897956.
  • Gil et al. 2002. Cell. 109(7):901-12. PMID: 12110186.
  • Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.