Cat. #151252
Anti-Kidins220 [p220 1F8/3]
Cat. #: 151252
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Kidins220/ARMS
Class: Monoclonal
Application: ELISA ; IHC ; IP ; WB
Reactivity: Rat
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Giampietro Schiavo
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Kidins220 [p220 1F8/3]
- Clone: p220 1F8/3
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 220 kDa
- Strain: Balb/c
- Reactivity: Rat
- Host: Mouse
- Application: ELISA ; IHC ; IP ; WB
- Description: Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
- Immunogen: Recombinant GST-Kidins220/ARMS (last 347 amino acids at the carboxy terminus) fusion protein.
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: Kidins220/ARMS
- Molecular weight: 220 kDa
- Target background: Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
Applications
- Application: ELISA ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Deswal et al. 2013. J Immunol. 190(5):1927-35. PMID: 23359496.
- Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.
- Bracale et al. 2007. Mol Biol Cell. 18(1):142-52. PMID: 17079733.
- Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.
- Iglesias et al. 2000. J Biol Chem. 275(51):40048-56. PMID: 10998417.
- Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.
