Anti-ICAM3 [ICAM 3.1]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-ICAM3 [ICAM 3.1]
• Alternate name: Intercellular Adhesion Molecule 3; ICAM-3; ICAM-R; CDW5; CD5
• Clone: ICAM 3.1
• Tool type ecom: Antibodies
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 130 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
• Description: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-3 is the major ligand for LFA-1 (CD11a/CD18) in the resting state. ICAM-3 may play a key role in initiating immune responses. ICAM 3.1 and ICAM 3.2 can be used to examine LFA-1/ICAM-3 adhesion.
• Immunogen: ICAM-3Fc chimeric fusion protein.
• Immunogen uniprot id: P26006
• Isotype: IgG1 kappa
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: ICAM3 (CD50)
• Molecular weight: 130 kDa
• Target background: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-3 is the major ligand for LFA-1 (CD11a/CD18) in the resting state. ICAM-3 may play a key role in initiating immune responses. ICAM 3.1 and ICAM 3.2 can be used to examine LFA-1/ICAM-3 adhesion.

Applications

• Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues.
• Increase in lymphoid follicles and leukocyte adhesion molecules emphasizes a role for the gut in spondyloarthropathy pathogenesis.
• Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1.