Anti-IL12 [1-1D5]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-IL12 [1-1D5]
• Alternate name: Interleukin 12; Cytotoxic Lymphocyte Maturation Factor 4 KDa Subunit; NK Cell Stimulatory Factor Chain; Interleukin-12 Beta Chain; IL-12 Subunit P4; CLMF P4; NKSF2; Natural Killer Cell Stimulatory Factor; IL12; Subunit P4; Interleukin 12; CLMF2; IMD29; NKSF; P4
• Clone: 1-1D5
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; IHC ; Fn ; RIA ; WB
• Description: IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL-12 plays a central role in cell-mediated immunity, promoting the differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL-12 is a potent stimulator of Natural Killer cells. IL-12 therapy has been suggested as a method of enhancing cytocidal anti-tumour immune responses.
• Immunogen: Recombinant human IL-12 produced by baculovirus.
• Immunogen uniprot id: P29459
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: Interleukin-12 (IL12) p40 subunit
• Target background: IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL-12 plays a central role in cell-mediated immunity, promoting the differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL-12 is a potent stimulator of Natural Killer cells. IL-12 therapy has been suggested as a method of enhancing cytocidal anti-tumour immune responses.

Applications

• Application: ELISA ; IHC ; Fn ; RIA ; WB

Handling

• Format: Liquid
• Concentration: 1mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Carter et al. 1997. Hybridoma. 16(4):363-9. PMID: 9309427.
• Production and characterization of monoclonal antibodies to human interleukin-12.