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{{/_source.additionalInfo}}Anti-AKT1 [V7]
(Cat#: 152617)
Description
Image: Staining of zebrafish skin using Anti-AKT1 [V7]. AKT1 can be seen to localize in the cytoplasm.
For Research Use Only.
| Cat# | 152617 |
| Applications | ELISA, IHC, WB |
| Antigen/Gene or Protein Targets | V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) |
| Reactivity | Zebrafish |
| Relevance | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide KDPMQRLGGG (C-terminal sequence) |
| Positive Control | ELISA - peptide immunogen; WB - whole organism lysate; IHC - zebrafish embryo |
| Subclass | IgG2a kappa |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Aquaculture, Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism, Neurobiology |
