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{{/_source.additionalInfo}}Anti-p53 [V5P4H6*B3]
(Cat#: 152613)
Description
| Cat# | 152613 |
| Applications | ELISA, IHC, WB |
| Antigen/Gene or Protein Targets | p53 |
| Reactivity | Zebrafish |
| Relevance | p53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide KLMVKDEGRS (C-terminal sequence) |
| Positive Control |
Western Blotting: whole Zebrafish lysate IHC: Zebrafish embryo |
| Subclass | IgG1 kappa |
| Research Area | Aquaculture, Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signaling |
Image: Immunohistochemistry using anti-p53 [V5P4H6*B3] on a Zebrafish embryo.
For Research Use Only.
