Anti-Golgin-97 [CDF4] monoclonal antibody
Invented by Martin Fritzler
Invented at University Of Calgary
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 157877 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Golgin 97 |
| Synonyms | Golgin subfamily A member 1 |
| Reactivity | Human and Rabbit |
| Relevance |
The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN). Golgin-97 resides on the cytoplasmic face of the Golgi and plays an essential role as tethering molecules on the TGN for retrograde traffic from the early and/or recycling endosomes. As a GRIP family member, Golgin-97 maintains cell polarity. Binding to the Golgi membrane is mediated by the G protein family member Arl1, and this pathway is a key regulatory process for endosome–TGN traffic. |
| Host | Mouse |
| Positive Control | IgG1 |
| Molecular Weight (kDa) | 88 |
| Notes | Golgin-97 is a peripheral membrane protein with a unique localization on the cytoplasmic face of the Golgi apparatus, which makes it a useful marker for immunodetection and identification of the Golgi apparatus in cells. |
| Research Area | Cell Type or Organelle Marker |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Martin Fritzler |
