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Anti-HDAC6-SE (159) mouse monoclonal antibody (SE domain-specific)

Invented at Institute of Biotechnology CAS

Info

Catalogue Number 157671
Applications ELISA IHC WB
Antigen/Gene or Protein Targets epitope in SE domain of histone deacetylase 6
Synonyms Histone deacetylase 6; HD6
Reactivity Human
Relevance The affinity purified mouse monoclonal antibody is immunospecific for the SE domain of human histone deacetylase 6 (HDAC6) as determined by ELISA, peptide library screening and Western blotting. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including α-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis.
Host Mouse
Immunogen human histone deacetylase 6 (sequence NP_006035.2)
Immunogen UniProt ID Q9UBN7
Subclass IgG
Research Area Cell Cycle, Cell Structure and Motility, Epigenetics & Nuclear Signalling

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