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Catalogue Number
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156373 |
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Antigen/Gene or Protein Targets
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TAM1
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Parental Line
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MCF-7
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Synonyms
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MCF7
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Host
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Human
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Tissue
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Breast
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Disease Keywords
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Breast Cancer; Tamoxifen Resistance
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Model
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Cancer Model
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Relevance
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Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF-7/TAM1 cell line shows an endogenous resistance to tamoxifen. The cells also exhibit an increased expression of Protein Kinase C alpha (PKCĪ±), which is an important player in tamoxifen resistant breast cancer.
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Research Area
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Cancer, Drug Discovery & Development
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Notes
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Engineered to over-express TAM1, which in turn causes over expression of PKCĪ±.
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