Anti-ICOS [4A.3A2] monoclonal antibody
Invented at Yale University
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Info
| Catalogue Number | 155247 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | inducible T-cell co-stimulator, CD278 |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody directed against ICOS, an immune checkpoint inhibitor. Background and Research Application ICOS (Inducible T-cell CO Stimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is an immune checkpoint expressed on activated T cells, which has opposing functions in sustaining T cell activation and in Treg suppressive activity. ICOS plays roles in cell-cell signalling, immune responses and regulation of cell proliferation. |
| Immunogen UniProt ID | Q9Y6W8 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Immunology |
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