Anti-Leu2 [C8/144B] recombinant antibody
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 154829 |
| Antigen/Gene or Protein Targets | Leu2 (CD8) |
| Synonyms | CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; CD8 Antigen; Alpha Polypeptide (P32); MAL; T-Cell Surface Glycoprotein CD8 Alpha Chain; Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen; T-Cell Antigen Leu2; T8 T-Cell Antigen; CD8a Antigen; Leu2; P32 |
| Reactivity | Human |
| Relevance | CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor/cytotoxic T cells which make up 30% of circulating T cells. C8/144B can be used to detect these cells in tissue sections and also their neoplastic counterparts. |
| Host | Mouse |
| Immunogen | Synthetic peptide (the 13 C-terminal residues of the cytoplasmic domain of human CD8a) |
| Subclass | IgG1 |
| Research Area | Immunology, Stem Cell Biology |
| Notes |
Western Blot (WB) 1:100-1:500 Immunohistochemistry (Paraffin) (IHC (P)) 1:50-1:100 Flow Cytometry (FACS) 2 ug/test |
References: 8 entries
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Harlin et al. 2009. Cancer Res. 69(7):3077-85. PMID: 19293190.
Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Mason et al. 1992. J Clin Pathol. 45(12):1084-8. PMID: 1479035.
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Sato et al. 2005. Proc Natl Acad Sci U S A. 102(51):18538-43. PMID: 16344461.
van Gool et al. 2015. Clin Cancer Res. 21(14):3347-55. PMID: 25878334.
Add a reference
References: 8 entries
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Harlin et al. 2009. Cancer Res. 69(7):3077-85. PMID: 19293190.
Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Mason et al. 1992. J Clin Pathol. 45(12):1084-8. PMID: 1479035.
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Sato et al. 2005. Proc Natl Acad Sci U S A. 102(51):18538-43. PMID: 16344461.
van Gool et al. 2015. Clin Cancer Res. 21(14):3347-55. PMID: 25878334.
Add a reference
