Anti-CD51 (Victronectin receptor ) [NKIM7] monoclonal antibody
Invented at Netherlands Cancer Institute
- Datasheet
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- Inventor Info
Info
| Catalogue Number | 154784 |
| Applications | FACS IHC IP |
| Antigen/Gene or Protein Targets | CD51 |
| Synonyms | ITGAV; Integrin Subunit Alpha V |
| Reactivity | Human |
| Relevance | ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction |
| Host | Mouse |
| Immunogen | Cultured melanoma cells derived from a human melanoma metastasis. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 116 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | RPMI +10% FBS ultra low IgG, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes |
Fusion partners: SP2/0 x spleen cells origin BALB/C. The antibody reacts strongly with melanoma cells derived from cell lines and short term cultures and melanoma cells in frozen tissue sections. |
| Research Area | Adhesion, Cell Structure and Motility, Immunology |
