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Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1] monoclonal antibody
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Info

Catalogue Number 154771
Applications FACS IP
Antigen/Gene or Protein Targets CD11b/CR3
Synonyms ITGAM; Leukocyte Adhesion Receptor MO1
Reactivity Human
Relevance ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.
αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
Host Mouse
Immunogen The mouse was immunized with purified human monocytes
Subclass IgG1
Molecular Weight (kDa) 160
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 1% ZAP, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C.
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology

References

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References: 1 entry

Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.


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References: 1 entry

Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.


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