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Anti-Integrin α-3B/6B [PB36] monoclonal Antibody
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Invented by Prof Arnoud Sonnenberg at Netherlands Cancer Institute

Info

Catalogue Number 154747
Applications IHC WB
Antigen/Gene or Protein Targets Integrin α3B and α6B
Synonyms ITGA3; ITGA6
Reactivity Human
Relevance ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
Host Mouse
Immunogen A mouse was immunized with a synthetic peptide corresponding to a 32 amino acid stretch in the cytoplasmic domain of integrin á3B including an appending N-terminal cysteine coupled to keyhole limpet hemocyanin.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FBS ultra low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse. PB36 recognizes the cytoplasmic domain of integrin subunits α3B and α6B. PB36 reacts with the basement membrane zone and endothelial cells in skin, tubuli in kidney and all vascular and capillary endothelia in brain and heart.
Research Area Adhesion, Cell Signaling & Signal Transduction

References

There are 1 reference entries for this reagent.

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References: 1 entry

de Melker et al. 1997. Lab Invest. 76(4):547-63. PMID: 9111516.


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References: 1 entry

de Melker et al. 1997. Lab Invest. 76(4):547-63. PMID: 9111516.


Add a reference