Anti-Cytokeratin 18 [DEK18] monoclonal Antibody
Invented by Prof Arnoud Sonnenberg from Netherlands Cancer Institute
Invented at Netherlands Cancer Institute
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 154746 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Cytokeratin 18 |
| Synonyms | KRT18; Keratin 18 |
| Reactivity | Dog, Human and Feline |
| Relevance | Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene |
| Host | Mouse |
| Immunogen | Cytoskeletal preperation extracted from humen epidermis |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 48 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 4% FBS ulta low IgG, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Fusion partners: SP2/0 myeloma x spleen cells origin BALB/C. This antibody reacts exclusively with cytokeratin18 is present in glandular epithelial cells of the digestive, respiratory, urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them. |
| Research Area | Cancer, Cell Structure and Motility |
References: 3 entries
Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206.
Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130.
Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472.
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References: 3 entries
Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206.
Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130.
Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472.
Add a reference
