Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse
Invented at Oklahoma Medical Research Foundation
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- References (2)
- Inventor Info
Info
| Catalogue Number | 154266 |
| Antigen/Gene or Protein Targets | Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans |
| Disease Keywords | Spontaneous Colitis-Associated Cancer, Colorectal Cancer, mucin, MUC2, Ulcerative Colitis, microbiome |
| Model | Knock-Out |
| Relevance | Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice |
| Production Details | Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans |
| Conditional | No |
| Growth/Phenotype Keywords | Spontaneous colitis-associated colon cancer |
| Strain | C57BL/6 |
| Mouse Genetic Background/Cross History | Core-3 intestinal derived O-glycan mice (C57BL/6-129Sv1mJ mixed background) were crossed with Core-1 intestinal derived O-glycan mice (C57BL/6J, 129/SvImJ mixed, C57BL/6J congenic) |
| Zygosity | unknown |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology, Other |
References: 2 entries
Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
Europe PMC ID: 27059389
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References: 2 entries
Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
Add a reference
