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Anti-SUMO-2/SUMO-3 (8A2) antibody

Info

Catalogue Number 153986
Applications ChIP IHC IF IP WB
Antigen/Gene or Protein Targets SUMO-2 and SUMO-3 but does not recognize SUMO-1
Synonyms Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Zentrin-2; Ubiquitin-like protein SMT3B; Smt3B
Reactivity Human
Relevance Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis.
Host Mouse
Immunogen Full length human recombinant protein of SUMO-2
Subclass IgG
Research Area Apoptosis and Programmed Cell Death, Cell Cycle, Cell Signaling & Signal Transduction, DNA Damage and Repair, Protein Degradation

References

There are 2 reference entries for this reagent.

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References: 2 entries

Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.

SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

Europe PMC ID: 18374647


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References: 2 entries

Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.

SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.


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