Anti-Dlg1, Polyclonal
Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 153963 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Dlg1 |
| Synonyms | Discs Large MAGUK Scaffold Protein, Synapse-Associated Protein 97, Discs Large Homolog 1, Scribble Cell Polarity Complex Component 2, Presynaptic Protein SAP97, Disks Large Homolog 1, SAP97 |
| Reactivity | Drosophila, Human and Rat |
| Relevance | hDlg1 is a mammalian homolog of the Drosophila discs large tumour suppressor protein which is intimately involved in the control of cell growth, maintenance of cell adhesion and cell polarity. In cells hDlg1 associates with the cortical cytoskeleton that underlies the plasma membrane at cell-cell adhesion sites. PDZ domains of hDlg1 have been shown to interact with the C-termini of several proteins including Shaker-type K+ channels, cytoskeletal protein 4.1 and the APC tumour suppressor protein. In addition hDlg1 has also been shown to interact with several viral oncoproteins including Adenovirus 9 E4ORF1 protein, HTLV-1 Tax and the high risk HPV E6 proteins. |
| Host | Rabbit |
| Immunogen | N-terminus aa 1-222 of rat Dlg |
| Formulation | Serum |
| Molecular Weight (kDa) | 107kDa |
| Notes |
WB 1:1000 IF 1:1000 |
| Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction |
References: 6 entries
Narayan et al. 2009. Virology. 387(1):1-4. PMID: 19307009.
The high-risk HPV E6 oncoprotein preferentially targets phosphorylated nuclear forms of hDlg.
Europe PMC ID: 19307009
Massimi et al. 2003. Exp Cell Res. 290(2):265-74. PMID: 14567986.
Redistribution of the discs large tumor suppressor protein during mitosis.
Europe PMC ID: 14567986
Mantovani et al. 2001. J Cell Sci. 114(Pt 23):4285-92. PMID: 11739660.
Proteasome-mediated regulation of the hDlg tumour suppressor protein.
Europe PMC ID: 11739660
Add a reference
References: 6 entries
Narayan et al. 2009. Virology. 387(1):1-4. PMID: 19307009.
The high-risk HPV E6 oncoprotein preferentially targets phosphorylated nuclear forms of hDlg.
Massimi et al. 2003. Exp Cell Res. 290(2):265-74. PMID: 14567986.
Redistribution of the discs large tumor suppressor protein during mitosis.
Mantovani et al. 2001. J Cell Sci. 114(Pt 23):4285-92. PMID: 11739660.
Proteasome-mediated regulation of the hDlg tumour suppressor protein.
Add a reference
