Anti-CYP450 Aromatase [H4]
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- References (22)
- Inventor Info
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| Catalogue Number | 153638 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | CYP450 Aromatase |
| Synonyms | Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19 |
| Reactivity | Human |
| Relevance | CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods. |
| Host | Mouse |
| Immunogen | Synthetic peptide corresponding to AAs 376-390 of human aromatase (KALEDDVIGYPVKK) |
| Positive Control | Placenta |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 55 |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Notes |
Suggested dilutions for use Western Blot 1:50-1:5000 Immunohistochemistry 1:50-1:100 Immunofluorescence 1:100 Immunocytochemistry 1:75 Research Areas: Endocrinology;Cancer;Fertility;Veterinary Science |
| Research Area | Cancer |
References: 22 entries
Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.
Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells.
Europe PMC ID: 29141657
Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.
Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).
Europe PMC ID: 23550169
Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.
The role of anti-Müllerian hormone (AMH) during follicle development in a monovulatory species (sheep).
Europe PMC ID: 22778215
Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.
Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.
Europe PMC ID: 20932560
Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.
Europe PMC ID: 20026603
Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.
Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.
Europe PMC ID: 19679653
Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.
Cytochrome P450arom, androgen and estrogen receptors in pig sperm.
Europe PMC ID: 17553131
Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.
Cytochrome P450 aromatase expression in human seminoma.
Europe PMC ID: 16372909
Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.
Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.
Europe PMC ID: 15941853
Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.
Steroid receptor and aromatase expression in baboon endometriotic lesions.
Europe PMC ID: 14505759
Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.
Development and validation of a new monoclonal antibody to mammalian aromatase.
Europe PMC ID: 11786371
Add a reference
References: 22 entries
Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.
Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells.
Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.
Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).
Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.
The role of anti-Müllerian hormone (AMH) during follicle development in a monovulatory species (sheep).
Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.
Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.
Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.
Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.
Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.
Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.
Cytochrome P450arom, androgen and estrogen receptors in pig sperm.
Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.
Cytochrome P450 aromatase expression in human seminoma.
Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.
Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.
Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.
Steroid receptor and aromatase expression in baboon endometriotic lesions.
Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.
Development and validation of a new monoclonal antibody to mammalian aromatase.
Add a reference