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Double Floxed Fbxw7/FoxM1

Info

Catalogue Number 153594
Antigen/Gene or Protein Targets Fbxw7 and foxM1
Disease Keywords Colorectal cancer
Synonyms F-box/WD repeat–containing protein 7, CDC4, Sel10, Ago, Fbw7, SCF, Skp1/Cullin/F-box protein, E3 ubiquitin ligase complex,FBW6, FBX30, FBXO30, FBXW6, SEL-10, hAgo, hCdc4, FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1
Model Conditional KO
Relevance FoxM1 is plays a key role in the cell cycle as endogenous expression peaks at the S and G2/M phases, crucial for mitotic division. Recent studies have shown that FOXM1 regulates expression of a large array of G2/M-specific genes which play a crucial role in maintenance of genomic stability and chromosomal segregation. There are 3 known isoforms of FoxM1, A, B & C and it is a known human proto-oncogene, involved in basal cell carcinoma.

Fbxw7 is a member of the F-box protein family, characterised by a motif of approximately 40 amino acids called the F-box. These proteins constitute one of the four subunits of ubiquitin protein ligase complex called SKP1-cullin-F-box and function in phosphorylation-dependent ubiquitination. Fbxw7 specifically protein contains 7 tandem solenoid protein domains also know as WD40 repeats. Fbwx7 binds directly to cyclin E and probably targets it for ubiquitin-mediated degradation.
Production Details This model was created by interbreeding the floxed-Fbxw7 mouse with a floxed-FoxM1 mouse (for floxed-FoxM1 mouse see references).
Conditional Yes
Conditional Description Requires expression of Cre recombinase to mediate excision of the lox P sites generating non-functional Fbxw7 and foxM1 proteins
Strain C57BL/6
Zygosity Homozygous
Research Area Cancer, Drug Discovery & Development, Metabolism

References

There are 4 reference entries for this reagent.

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References: 4 entries

Yoshida et al. 2007. Gastroenterology. 132(4):1420-31. PMID: 17408638.

The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.

Europe PMC ID: 17408638

Wang et al. 2002. Proc Natl Acad Sci U S A. 99(26):16881-6. PMID: 12482952.

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.

Europe PMC ID: 12482952


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References: 4 entries

Yoshida et al. 2007. Gastroenterology. 132(4):1420-31. PMID: 17408638.

The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.

Wang et al. 2002. Proc Natl Acad Sci U S A. 99(26):16881-6. PMID: 12482952.

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.


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