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Anti-CD11a [BU17]

Invented by Dr Margaret Goodall at University Of Birmingham

Info

Catalogue Number 153581
Applications FACS
Antigen/Gene or Protein Targets CD11a
Synonyms Integrin alpha L; lymphocyte function-associated antigen 1 alpha polypeptide; ITGAL; cell differentiation 11a
Reactivity Human
Relevance CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands.
Host Mouse
Immunogen Waldenstroms macroglobulinaemia a late B cell line with surface and secreted IgM Kappa
Subclass IgG1
Notes Fusion partner: 653
Research Area Cell Signaling & Signal Transduction

References: 4 entries

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Europe PMC ID: 11342414

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.

Europe PMC ID: 9763568


Add a reference

References: 4 entries

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Europe PMC ID: 11342414

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.

Europe PMC ID: 9763568


Add a reference

References: 4 entries

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.


Add a reference


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