Anti-EGFR [ICR11]
Invented at The Institute of Cancer Research
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Info
| Catalogue Number | 153387 |
| Applications | FACS IHC IP |
| Antigen/Gene or Protein Targets | EGFR |
| Synonyms | ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61 |
| Reactivity | Human |
| Relevance | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
| Host | Rat |
| Immunogen | Squamous cell carcinoma |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 42.4 |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
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