Anti-LewisA, Recombinant [PR 5C5]
Invented at University of Oxford
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153276 |
| Applications | ELISA IHC |
| Antigen/Gene or Protein Targets | Lewis A antigen |
| Reactivity | Human |
| Relevance | Lewis a antigen is expressed on colonic mucus, epithelial cells and cell membranes. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours. |
| Host | Mouse |
| Immunogen | Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29. |
| Subclass | IgG1 |
| Formulation | PBS |
| Concentration | 1mgml-1 |
| Research Area | Cancer, Immunology |
| Notes |
Recommended for use with formalin fixed tissues. Recombinant monoclonal antibody produced from the original monoclonal cell line. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Five products available for this clone: - Anti-Lewis A [PR 5C5], Mouse IgG1, Kappa - Anti-Lewis A [PR 5C5], Rabbit IgG, Kappa - Anti-Lewis A [PR 5C5], Human IgG4-S228P, Kappa - Anti-Lewis A [PR 5C5], Human IgG1, Kappa - Anti-Lewis A [PR 5C5], Human IgG1, Kappa, engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors |
References: 1 entry
Original hybridoma first published in: Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.
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References: 1 entry
Original hybridoma first published in: Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.
Add a reference
