Anti-HLA-DRB1 [DJ9]
Invented at University Of Southern Denmark
- Datasheet
- References (2)
- Inventor Info
Info
![Flow cytometry analysis of human mesenchymal stem cells (upper) and skin fibroblasts (lower) using anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/5d26f1e9-1836-4fbc-a03e-c3fc24ea8926.png)
![Immunohistochemistry (P) on human mesenchymal stem cells (upper) and skin fibroblasts (lower) using anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/346db5ae-96a8-40d1-8971-fd4c711a821e.png)
![Flow cytometry analysis of human mesenchymal stem cells (upper) and skin fibroblasts (lower) using anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/5d26f1e9-1836-4fbc-a03e-c3fc24ea8926.png)
![Immunohistochemistry (P) on human mesenchymal stem cells (upper) and skin fibroblasts (lower) using anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/346db5ae-96a8-40d1-8971-fd4c711a821e.png)
![Image thumbnail for Anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/5d26f1e9-1836-4fbc-a03e-c3fc24ea8926.png)
![Image thumbnail for Anti-HLA-DRB1 [DJ9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/346db5ae-96a8-40d1-8971-fd4c711a821e.png)
| Applications | FACS IHC IF WB |
| Antigen/Gene or Protein Targets | Human major histocompatibility complex class II, DR (HLA-DRB1) |
| Synonyms | Major histocompatibility complex, class II, DRB1 |
| Reactivity | Human |
| Relevance | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. HLA-DRB1 binds peptides derived from antigens that access the endocytic route of antigen presenting cells and presents them on the cell surface for recognition by the CD4 T-cells. Class II molecules are expressed in antigen presenting cells B lymphocytes, dendritic cells, macrophages. HLA-Drb1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. HLA-DRB1, clone DJ9, has been shown to be a relevant marker of bone marrow derived mesenchymal stem cells and their osteogenic derivatives (Andersen, D., et al., 2011). |
| Host | Mouse |
| Immunogen | Whole, intact hMSC-TERT Cells |
| Subclass | IgG2a lambda |
| Notes | Epitope: The epitope is on the extracellular side of the HLA-DRB1 molecule |
| Research Area | Immunology |
References: 2 entries
Andersen et al. 2011. Mol Cells. 32(2):133-42. PMID: 21614487.
Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells.
Europe PMC ID: 21614487
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References: 2 entries
Andersen et al. 2011. Mol Cells. 32(2):133-42. PMID: 21614487.
Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells.
Add a reference
