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Monoclonal Antibodies

Anti-CHIKV [3E7b]

Invented at A*STAR Accelerate Technologies Pte Ltd
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Anti-CHIKV IgM (3E7b) and (8A2c) are used to stained chikungunya virus-infected cell. There is no staining observed in the mock infected cells. DAPI was used to stain the nucleus of the cells.
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Catalogue Number 153198
Applications ELISA IHC Fn WB
Antigen/Gene or Protein Targets N218 epitope on E2 protein of CHIKV
Synonyms Chikungunya virus
Reactivity Virus
Relevance Monoclonal antibody capable of neutralising CHIKV replication and can detect infection of cells.

Background and Research Application
Chikungunya virus (CHIKV) is an alphavirus which causes febrile illness with severe polyarthralgia, known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4–7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhoea, vomiting and rash. CHIKV gained its infamy from the severe outbreak in the Indian Ocean island of La Re’union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced haemorrhagic fever manifestations. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa.

Anti-CHIKV binds strongly to native CHIKV surface and potently neutralize CHIKV replication.
Host Mouse
Immunogen Live chikungunya virus
Immunogen UniProt ID Q8JUX5
Positive Control Infected BHK cells
Subclass IgM
Myeloma Used Sp2/0-Ag14
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
Mouse monoclonal antibodies that are specific to chikungunya virus can be used as a research or diagnostic reagent to detect infection of cells.

Concentration
1mg/ml as standard
Research Area Parasitology, Virology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Schultz et al. 2020. Viruses. 12(3):. PMID: 32120905.

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Jin et al. 2019. Viruses. 11(4):. PMID: 30925717.

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A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis.

Europe PMC ID: 26305993

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Lam et al. 2015. MAbs. 7(6):1178-94. PMID: 26305993.

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References: 4 entries

Schultz et al. 2020. Viruses. 12(3):. PMID: 32120905.

View  

Jin et al. 2019. Viruses. 11(4):. PMID: 30925717.

View  

A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis.

View  

Lam et al. 2015. MAbs. 7(6):1178-94. PMID: 26305993.

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Inventor Information

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Invented at

A*STAR Accelerate Technologies Pte Ltd
A*STAR Accelerate Technologies Pte Ltd

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