Anti-Phospho-Rb (Thr356) [7F10]
Invented by Prof Sibylle Mittnacht from University College London
Invented at The Institute of Cancer Research
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153190 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Rb (phospho Thr356) |
| Synonyms | Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC |
| Reactivity | Human and Mouse |
| Relevance | Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4. |
| Host | Rat |
| Immunogen | Synthetic peptide COOH-C-ERERpTPRKNN-NH2 coupled to mycobacterium tuberculosis PPD |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 111 |
| Research Area | Cancer, Cell Cycle, Cell Signaling & Signal Transduction, Gene Expression, Stem Cell Biology |
References: 2 entries
Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Europe PMC ID: 12895470
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References: 2 entries
Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Add a reference
Inventor Information
Inventors
|
Prof Sibylle Mittnacht |
