Anti-CD45RA [BU77]
Invented at University Of Birmingham
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Info
| Catalogue Number | 153172 |
| Applications | FACS IHC |
| Antigen/Gene or Protein Targets | Protein tyrosine phosphatase receptor type C |
| Synonyms | PTPRC, CD45RA |
| Reactivity | Human |
| Relevance | CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is expressed on naïve T cells, as well as the effector cells in both CD4 and CD8. CD45RA is an isoform of the PTPRC complex which is selectively expressed on B cells. |
| Host | Mouse |
| Immunogen | Perpheral Blood B cells |
| Subclass | IgG2a |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Strain | Balb/c |
| Notes | Similar to BU82 and BU78 |
| Research Area | Cell Type or Organelle Marker, Immunology, Stem Cell Biology |
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