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Anti-HAND1, Polyclonal [HAND1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets HAND1
Reactivity Human and Mouse
Relevance Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac­specific genes. Binds the DNA sequence 5'­NRTCTG­3' (non­canonical E­box). The protein encoded by this gene belongs to the basic helix­loop­helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq]  
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 23.6
Research Area Cardiovascular, Developmental Biology, Epigenetics & Nuclear Signalling, Stem Cell Biology

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