Anti-CD11b [2LPM19c]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 152935 |
| Applications | FACS IHC |
| Antigen/Gene or Protein Targets | Cluster of Differentiation 11b (CD11b) |
| Synonyms | CD11b, Integrin alpha M, Integrin aM, Mac-1 a subunit, C3bi receptor, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor |
| Reactivity | Human |
| Relevance |
CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, Mß2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain. |
| Host | Mouse |
| Immunogen | Purified C3bi receptor |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 127 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + glutamine (2mM) + HAT |
| Research Area | Adhesion, Apoptosis and Programmed Cell Death, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology |
References: 6 entries
Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.
c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.
Europe PMC ID: 11031208
Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.
Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.
Europe PMC ID: 7673724
Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
Europe PMC ID: 7679388
Add a reference
References: 6 entries
Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.
c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.
Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.
Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.
Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
Add a reference
