Anti-Beta amyloid 1-42 [12F4]
Invented at Icahn School Of Medicine At Mount Sinai
- Datasheet
- References (4)
- Inventor Info
Info
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Beta amyloid 42 |
| Synonyms | ABETA, ABPP, AD1, Adap, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), Alzheimer disease amyloid protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, APP, APPI, Beta amyloid protein 40, Beta APP40, Beta-APP40, Beta-APP42, BetaAPP, C31, Cerebral vascular amyloid peptide |
| Reactivity | Mouse and Human |
| Relevance | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. |
| Host | Mouse |
| Subclass | IgG1 |
| Research Area | Adhesion, Apoptosis and Programmed Cell Death, Cell Structure and Motility, Neurobiology, Protein Degradation |
References: 4 entries
Koronyo-Hamaoui et al. 2011. Neuroimage. 54 Suppl 1:S204-17. PMID: 20550967.
Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.
Europe PMC ID: 20550967
Sudol et al. 2009. Mol Ther. 17(12):2031-40. PMID: 19638957.
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Europe PMC ID: 19638957
Add a reference
References: 4 entries
Koronyo-Hamaoui et al. 2011. Neuroimage. 54 Suppl 1:S204-17. PMID: 20550967.
Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.
Sudol et al. 2009. Mol Ther. 17(12):2031-40. PMID: 19638957.
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Add a reference
