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Anti-Erythrocyte [34-3C]

Info

Applications IF Fn
Antigen/Gene or Protein Targets Erythrocytes
Reactivity Mouse
Relevance Anti-Erythrocyte [34-3C] is a monoclonal autoantibody-secreting hybridoma established from unmanipulated autoimmune-prone NZB mice.

The antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
Host Mouse
Immunogen Mouse erythrocytes
Subclass IgG2a
Notes Useful for establishing in vivo model of haemolytic anaemia.
Research Area Immunology

References: 2 entries

Shibata et al. 1990. Int Immunol. 2(12):1133-41. PMID: 2090198.

Fn

Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms.

Europe PMC ID: 2090198


Add a reference

References: 2 entries

Shibata et al. 1990. Int Immunol. 2(12):1133-41. PMID: 2090198.

Fn

Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms.

Europe PMC ID: 2090198


Add a reference

References: 2 entries

Shibata et al. 1990. Int Immunol. 2(12):1133-41. PMID: 2090198.

Fn

Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms.


Add a reference


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