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|Antigen/Gene or Protein Targets||Erythrocytes|
Anti-Erythrocyte [34-3C] is a monoclonal autoantibody-secreting hybridoma established from unmanipulated autoimmune-prone NZB mice.
The antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
|Notes||Useful for establishing in vivo model of haemolytic anaemia.|
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