Anti-SLA2 [Z30P1F12*F4]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Info
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded pancreatic adenocarcinoma tissue using anti-SLA2 [Z30P1F12*F4]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/353f2a3f-c41e-47c5-a55d-98e000dbb89d.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-SLA2 [Z30P1F12*F4].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/64a2fdb8-3f02-4d0b-8765-5a2859e9c764.jpg)
![Immunohistochemistry photos are showing immunostaining of Anti-SLA2 [Z30P1F12*F4] in normal colon mucosa and primary colorectal tumour. A variation of immunostaining intensity between cases is observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/1465db6c-4ee0-49cf-a6bd-de3f142eef03.png)
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded pancreatic adenocarcinoma tissue using anti-SLA2 [Z30P1F12*F4]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/353f2a3f-c41e-47c5-a55d-98e000dbb89d.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-SLA2 [Z30P1F12*F4].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/64a2fdb8-3f02-4d0b-8765-5a2859e9c764.jpg)
![Immunohistochemistry photos are showing immunostaining of Anti-SLA2 [Z30P1F12*F4] in normal colon mucosa and primary colorectal tumour. A variation of immunostaining intensity between cases is observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/1465db6c-4ee0-49cf-a6bd-de3f142eef03.png)
![Image thumbnail for Anti-SLA2 [Z30P1F12*F4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/353f2a3f-c41e-47c5-a55d-98e000dbb89d.jpg)
![Image thumbnail for Anti-SLA2 [Z30P1F12*F4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/64a2fdb8-3f02-4d0b-8765-5a2859e9c764.jpg)
![Image thumbnail for Anti-SLA2 [Z30P1F12*F4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/1465db6c-4ee0-49cf-a6bd-de3f142eef03.png)
| Catalogue Number | 152758 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Src-Like-Adaptor 2 (SLA2) |
| Synonyms | Modulator of antigen receptor signaling (MARS), Src-like adapter protein 2 (SLAP-2), SLA-2 |
| Reactivity | Human |
| Relevance | SLA2 (Src-like-adapter 2), also known as C20orf156 or SLAP2, is a 261 amino acid protein that exists as four alternatively spliced isoforms which localize to either the cytoplasm or to the cell membrane and contain one SH2 domain and one SH3 domain. Expressed predominately in tissues of the immune system, including thymus, spleen and lymph nodes, SLA2 functions as an adaptor protein that negatively regulates T-cell receptor (TCR) signaling and may inhibit T-cell activation. SLA2 interacts with Zap-70 and is subject to posttranslational phosphorylation. The gene encoding SLA2 maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. |
| Host | Mouse |
| Immunogen | Peptide Sequence – LRESLSFY |
| Positive Control | Jurkat cell lysate |
| Subclass | IgG |
| Molecular Weight (kDa) | 29 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Immunology |
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