Anti-JMY [HMY117]
Invented by Helen Turley from University of Oxford
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152747 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | JMY |
| Reactivity | Human |
| Relevance | The anti-JMY [HMY117] antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. It might act either as tumor suppressor or as oncogene. This antibody may be used in research but also as a diagnostic tool. |
| Host | Mouse |
| Immunogen | Synthetic peptide from the c terminus of the peptide sequence, identical for both isoform 1 and 2 |
| Positive Control | MCF7, HeLa |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Research Area | Apoptosis and Programmed Cell Death |
References: 2 entries
Adighibe et al. 2014. Virchows Arch. 465(6):715-22. PMID: 25280461.
JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
Europe PMC ID: 25280461
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References: 2 entries
Adighibe et al. 2014. Virchows Arch. 465(6):715-22. PMID: 25280461.
JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
Add a reference
