Anti-Leu2, Recombinant [UCH-T4]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152731 |
| Applications | FACS IHC IF |
| Antigen/Gene or Protein Targets | Leu2 (CD8) |
| Reactivity | Human |
| Relevance | Leu-2 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. Leu-2 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. UCH-T4 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc. |
| Host | Mouse |
| Immunogen | Thymocytes followed by Sezary T cells. |
| Subclass | IgG1 |
| Research Area | Immunology, Stem Cell Biology |
| Notes |
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Three different versions available: - Anti-CD8 [UCHT4], Mouse IgG2a, Kappa - Anti-CD8 [UCHT4], Mouse IgG2a, Kappa, containing key point mutations that abrogate binding to Fc gamma receptors. - Anti-CD8 [UCHT4], Rabbit IgG, Kappa |
References: 2 entries
Original hybridoma first published in: Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.
beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.
Europe PMC ID: 10797569
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References: 2 entries
Original hybridoma first published in: Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.
beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.
Add a reference
