Anti-Keratin 1 [LL017]
Invented by Prof Irene Leigh from Queen Mary University of London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 152683 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | Keratin 1, Cytokeratin 1 |
| Reactivity | Human |
| Relevance | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification. |
| Host | Mouse |
| Immunogen | Synthetic peptide - VSTTYSGVTR |
| Subclass | IgM |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Use immunoperoxidase on frozen sections. |
| Research Area | Cell Signaling & Signal Transduction |
References: 8 entries
de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.
IHC
Keratin expression in discoid lupus erythematosus.
Europe PMC ID: 8608342
Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
IHC
Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
Europe PMC ID: 7544603
Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
Keratin expression in basal cell carcinomas.
Europe PMC ID: 1371396
Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.
IHC
Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.
Europe PMC ID: 1721080
Add a reference
References: 8 entries
de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.
IHC
Keratin expression in discoid lupus erythematosus.
Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
IHC
Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
Keratin expression in basal cell carcinomas.
Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.
IHC
Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.
Add a reference
