Anti-mib [6B2]

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Catalogue Number	152640
Applications	WB
Antigen/Gene or Protein Targets	mind bomb
Reactivity	Zebrafish
Relevance	Zebrafish mind bomb (mib) was isolated in a large-scale screen aiming for morphologically discernible phenotypes. Mib mutants have phenotypes similar to Notch pathway mutants: a dramatic increase of primary neurons and somatic segmentation abnormalities. mib was positional cloned to be a novel gene. Mib is a novel E3 ligase with three Ring Finger (RF) domains in the C-terminal. Mib can interact with Delta, a Notch ligand. The interaction will mediate a RF-dependent ubiquitination and endocytosis of Delta, and thus effectively activates Notch in neighbouring cells. In addition, there are a series of mib alleles with different genetic severity. The most severe phenotype of antimorphic mibta52b allele is partly due to the antagonization of a second Mib homolog, Mib2, by Mibta52b protein.
Host	Mouse
Immunogen	GST fusion-Fish mib protein
Positive Control	Zebrafish
Subclass	IgG2b
Myeloma Used	Sp2/0-Ag14
Research Area	Aquaculture

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	A*STAR Accelerate Technologies Pte Ltd
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