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Anti-ROS-CII, Recombinant [1-11E/vIL-10]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets ROS-Collagen II
Reactivity Mouse
Relevance Anti-ROS-CII, Recombinant [1-11E/vIL-10] is a unique ScFv/antibody highly specific for disease-modified collagen II (found in arthritis patients). It has been used to facilitate targeted delivery of therapy to arthritic joints.Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Research Area Cell Structure and Motility
Notes Viral interleukin-10 (vIL-10) was fused to anti-ROS-CII (1-11E) with a matrix-metalloproteinase (MMP) cleavable linker to create 1-11E/vIL-10 fusion.

References: 2 entries

Hughes et al. 2014. Arthritis Res Ther. 16(4):R151. PMID: 25029910.

ELISA IHC IF WB

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.

Europe PMC ID: 25029910


Add a reference

References: 2 entries

Hughes et al. 2014. Arthritis Res Ther. 16(4):R151. PMID: 25029910.

ELISA IHC IF WB

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.

Europe PMC ID: 25029910


Add a reference

References: 2 entries

Hughes et al. 2014. Arthritis Res Ther. 16(4):R151. PMID: 25029910.

ELISA IHC IF WB

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.


Add a reference


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