Anti-ROS-CII, Recombinant [1-11E/vIL-10]
Invented at Queen Mary University of London
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- References (2)
- Inventor Info
Info
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | ROS-Collagen II |
| Reactivity | Mouse |
| Relevance | Anti-ROS-CII, Recombinant [1-11E/vIL-10] is a unique ScFv/antibody highly specific for disease-modified collagen II (found in arthritis patients). It has been used to facilitate targeted delivery of therapy to arthritic joints.Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
| Research Area | Cell Structure and Motility |
| Notes | Viral interleukin-10 (vIL-10) was fused to anti-ROS-CII (1-11E) with a matrix-metalloproteinase (MMP) cleavable linker to create 1-11E/vIL-10 fusion. |
References: 2 entries
Hughes et al. 2014. Arthritis Res Ther. 16(4):R151. PMID: 25029910.
ELISA IHC IF WB
Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.
Europe PMC ID: 25029910
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References: 2 entries
Hughes et al. 2014. Arthritis Res Ther. 16(4):R151. PMID: 25029910.
ELISA IHC IF WB
Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.
Add a reference
